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In accounting for these findings, our own molecular modelling of the known sites for 4-HNE adduction within tubulin indicate that this form of modification is likely to cause both changes in the tertiary structure of the protein and importantly, alter the surface characteristics of the tubulin monomers

Alfonso Pierola A, Montalban-Bravo G, Chamseddine AN, Takahashi K, Wang F, Xingzhi S, Jabbour EJ, Kadia TM, Ravandi F, Cortes JE, DiNardo CD, Daver NG, Borthakur G , Pemmaraju N, Konopleva M, Bueso-Ramos CE, Patel K, Futreal A, Pierce S, Kantarjian HM, Garcia-Manero G

10 Cysteine and methionine Cysteine is a sulfur-containing amino acid that can be either obtained from dietary sources or synthesized via the transsulfuration pathway

Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus

336 The age-dependent decline of NAD + might be due to either enhanced consumption or reduced biosynthesis