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For example, activation of transient receptor potential ankyrin 1 (TRPA1) induces Ca influx, promoting calmodulin-dependent protein kinase II (CaMKII) phosphorylation, and Nrf2 nuclear translocation, which upregulates GPX4 to inhibit ferroptosis in high-glucose-exposed endothelial cells, thereby improving cell migration, proliferation, and tube formation to enhance diabetic wound healing [87]

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10.1016/j.preteyeres.2022.101063 [DOI] [PMC free article] [PubMed] [Google Scholar] 269.Abu-Hassan DW Li X, Ryan EI, Acott TS, Kelley MJ