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doi: 10.1016/j.arr.2012.10.004

Moreover, psammaplin, a group of natural products isolated from the marine sponge pseudoceratina purpurea , have been reported to inhibit both DNMTs and HDAC with mild toxicity (68)

61 FujisawaK.KuriharaN.NishikawaH.KimuraA.KojimaM

Decreased protein intake affects the availability of zinc, which is a cofactor of SOD

Another advantage of this model is that the effects can be analyzed at the level of specific immune cell subtypes, offering the possibility of identifying cells that are most sensitive to chemical effects