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Essentially, both the presence of thick bronchiolar mucus and bacterial biofilm contribute to poor lung penetration of antimicrobial agents, thus leading to clinical aggravation and inefficacy of the therapies

This not only leads to a significant increase in ROS generation but also further amplifies the local inflammatory response by releasing pro-inflammatory signals (81)

One key challenge was replicating the success experienced in Arizona across new markets

Furthermore, therapeutic application of BV includes their use in the management of bursitis, tendonitis, dissolving scar tissue, in the management of post herpetic neuralgia, Lyme disease, rheumatoid arthritis, osteoarthritis, multiple sclerosis, TMDs, and more (Table 5) (Kurek-Grecka et al., 2020)