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The exact pathophysiology of the RLS is still not clear, but some superficial assumptions regarding the progressions of disease and root of disease through the gene molecular concepts

Replenishing GSH levels has been shown to protect the brain, slow neurodegeneration, and even repair damage

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Notably, area-specific LPS-induced inflammation in the intestine has been identified, and a unique gene signature may be useful to determine the affected intestinal region ( Supplementary Table 1 ) in the large intestine (109, 197)