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Stress, hypercortisolism and corticosteroid receptors in depression: implications for therapy

Additionally, NLRP3 (NOD-like receptor family, pyrin domain-containing 3), an inflammasome protein complex involved in the activation of inflammatory responses is activated in PD leading to the release of pro-inflammatory cytokines, including IL-1, which may contribute to neuronal damage and progression of the disease (Khot, et al