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Phase II study of a liposome-entrapped cisplatin analog (L-NDDP) administered intrapleurally and pathologic response rates in patients with malignant pleural mesothelioma

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It also enhances cellular permeability, causes DNA damage through the generation of bulky adducts like N2-acetaldehyde deoxyguanine, alters the activity of enzyme convertases, and disrupts cellular oxidative balance by binding to glutathione reductase, resulting in lipid peroxidation and the formation of hydroxyl radicals [184]

Repeated administration of steroid-containing injections can cause joint degeneration over time