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Chemical modifications of nucleic acid drugs and their delivery systems for gene-based therapy

Notably, further LPS challenge in XBP1-overexpressing mice produces only modest additional increases in NGAL and CHOP compared with LPS alone, indicating that amplified XBP1 signaling selectively drives the inflammatory and injurious aspects of septic AKI (156)

1 2 Digestion of fats (triacylglycerols) "The function of bile salts in fat absorption

Current treatment relies heavily on antibiotics, however, the rapid emergence of multidrug-resistant strains has severely compromised their efficacy, underscoring the urgent need for alternative therapeutic strategies

In: Katazung's Basic and Clinical Pharmacology