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We further excluded two variants located in C1orf109 and TMEM161A genes, as the variant in C1orf109 was found 11 in homozygous state in the gnomAD database (v4.1.0), and the TMEM161A variant did not segregate with the phenotype

[DOI] [PubMed] [Google Scholar] 76.Appelhoff RJ, et al

Testing the ability of non-methylamine osmolytes present in kidney cells to counteract the deleterious effects of urea on structure, stability and function of proteins