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There was a statistically significant antidotal effect of the vitamin

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Remarkably, after 48h food deprivation, GO-CoA-Tat attenuated food foraging, food intake, and food hoarding post-refeeding relative to animals treated with saline

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In the same group, B12-downregulated genes had GO annotations related to NF-kappaB signaling, T-cell receptor signaling pathway and negative regulation of histone H3-K9 trimethylation ( Figure S3 )