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It is naturally produced in humans and found in the hypothalamus, pituitary, gut, plasma, cerebrospinal fluid, and breast milk, with levels following a circadian rhythm peaking in the late afternoon

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Intern Med 165 , 13631369 (2005)

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Thus, the transcription and DNA replication are disturbed, leading to the induction of apoptosis

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Telomeres are the protective caps at the ends of chromosomes

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