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6b,c), demonstrating successful NAM incorporation and fluorescence modification on the E

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The 5-on, 2-off schedule mirrors the natural rhythm of the week and prevents receptor desensitization over a long cycle

Iron overload increases ferritin levels and decreases RUNX2 levels in BMSCs, causing irregular morphological changes, significantly reducing their activity, and inhibiting osteogenic differentiation, while melatonin therapy could reverse this process and promote osteogenic differentiation of BMSCs