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T cell exhaustion has not been associated with tumoral GPX4 expression, but as our DIO study indicated greater numbers of PD1+/TIM3 + CD8 + T cells in shGPX4 tumors, this finding could be a diet-specific effect

Trotti LM, Staab BA, Rye DB

Pure cerebellar ataxia was presented in two cases, while five showed extracerebellar symptoms, including psychiatric symptoms (three case), cognitive dysfunction (two cases), generalized seizures (one case), and retinopathy (one case)

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Talk to your veterinarian: this step is paramount