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Functional deficiency of astrocytic glutamate clearance and K + buffering is the primary cause of neuronal damage in neurodegenerative diseases, most notably in amyotrophic lateral sclerosis (ALS) and Huntingtons disease (HD) 148,149,150,151,152,153 , whereas functional asthenia of astrocytes may exacerbate -amyloid pathology in the context of Alzheimers disease (AD) 154