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Examples of drugs without the package type terms and discard statements included certain manufacturers of digoxin injection (approved in 1954), oxytocin injection (approved in 1980), diphenhydramine hydrochloride injection (approved in 1982), phenobarbital sodium injection (orphan drug without FDA approval)

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Goal: Maintain testicular volume and function during TRT Approach: HCG 500 IU subcutaneously every other day (3x weekly) Begin same time as testosterone therapy Continue for duration of TRT Monitoring: Baseline testosterone, estradiol, LH, FSH Recheck at 6 weeks, then quarterly Adjust based on estrogen response Expected results: Maintained testicular size Preserved fertility potential Possible slight testosterone boost above TRT alone Protocol for fertility restoration on TRT Men on TRT who want to conceive face a decision