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In the brain, they are considered key mediators in regulating the inflammatory activity of microglia during the pathological process of IS [109]

94 Moreover, SLC1A3 is mainly expressed in brain tissue, and its high expressions in some solid tumors, such as clear cell renal cell carcinoma, papillary renal cell carcinoma, hepatocellular carcinoma and gastric adenocarcinoma, may make SLC1A3 inhibitors a solution to ASNase resistance