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This dysregulation is systemically reflected by a marked elevation in CP, a key copper-transporting acute-phase protein and a recognized clinical biomarker of sepsis [176]

In melanoma, the oncogenic mutation of BRAF promotes metabolic reprogramming [8, 9], thereby often favouring glycolysis for energy production

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dysregulation of this balance leads to chronic low-grade inflammation and impaired immune function ( In the present study, the 0.4 and 0.6 g/kg KAE groups significantly increased serum IL-4 levels and decreased serum IL-1 levels ( p 0.05)