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Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

Furthermore, the ethical constraints of testing novel therapies in pregnant populations, given potential fetal harm, limit the available translational pathways, exacerbating the gap between preclinical promise and clinical application [68]

Weak: Limited human data + reliance on animal studies

Potentially adjunctive therapy for cancer But even with these benefits, potential nutrient deficiencies have been shown to occur with keto and other restricted diets, especially when these diets are prolonged

After about four weeks, the dose can be increased to 0.5 mg or more if needed