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The 95% confidence intervals were calculated using Hotellings T 2 with the R package car 44 using an R script available from Identification and quantitative analysis of alkaloids in kratom plant material Standard solutions of mitragynine and 7-hydroxymitragynine were purchased from MilliporeSigma (St

Selim et al., 2019

PMID 16443160

Disturbed cell fate regulation: apoptosis, autophagy and epigenetic alterations During ovarian aging, mitochondrial dysfunction, ROS accumulation and mtDNA damage significantly activate the endogenous apoptotic pathway, as evidenced by an elevated Bax/Bcl-2 ratio, activation of caspase-3/9 and Cyt c leakage [334]