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Access this article Similar content being viewed by others References Papers of particular interest, published recently, have been highlighted as: Of importance Of major importance Devine CJ Jr, et al

The accumulation of misfolded protein in the endoplasmic reticulum (ER) leads to ER dysfunction, which is known as ER stress ( 12 regulated ER homeostasis ( 12 deficiency activated ER stress pathways by increasing the phosphorylation of PERK and IRE1 and the expression of ATF6 ( 12 could promote nerve regeneration after TBI by regulating ER stress

A further link between VitB12 and neuroinflammation is given by the resulting increase in HCy after deficiency

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