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Topalian SL, Sznol M, McDermott DF, Kluger HM, Carvajal RD, Sharfman WH, Brahmer JR, Lawrence DP, Atkins MB, Powderly JD, et al

Animal studies have shown good tolerability across multiple administration routes including oral, intraperitoneal, intramuscular, and topical applications

Glob Chang Biol 18:118126

180 Deep brain stimulation involves the use of electrodes implanted in the brain to deliver electrical impulses directly to specific brain regions, and is under investigation as a treatment option for individuals with obsessive-compulsive disorder and post-traumatic stress disorder

Most of the studies done so far have been in rodents -- results that dont always hold up when larger studies are done in people