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Key mechanisms include the inhibition of PD-L1 expression and the modulation of NF- B/SHIP-1 signaling pathway, which collectively enhance the efficacy of cancer immunotherapy (Table 1)

Hepatology 72 , 656670 (2020)

Studies found that EpCAM-low CTCs had reduced proliferation but increased migration, suggesting these cells have a higher potential for metastasis [6]

A small fraction is metabolized by cytochrome P450 enzymes (mainly CYP2E1) to form a reactive intermediate, N-acetyl-p-benzoquinone imine (NAPQI), which is then detoxified by conjugation with glutathione