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The oxidative potential (OP) values observed in this study are broadly consistent with those reported in previous tunnel and urban PM studies, despite differences in methodology

Whole blood and RBC cytosolic fractions

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Our findings describe a role for mitochondrial plasticity as a mechanism for acute 5FU tolerance in CRC cells: mitochondrial changes acutely adopted by CRC cells in response to 5FU-based standard-of-care treatment result in increased mitochondrial biogenesis, which provides metabolic support for increased pyrimidine scavenging by UCK2 to resolve nucleotide stress