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Nave B cells recruited by chemokines such as CXCL13 migrate to distinct zones, where they form germinal centers and produce antibodies to an almost limitless repertoire of antigens ( Figure 1 ) ( Figure 1 Tertiary lymphoid structures (TLSs), though not strictly lymph nodes, are also involved in anti-tumor immunity

Three DNA methyltransferase enzymes catalyze DNA methylation: Dnmt1, Dnmt3a, and Dnmt3b, which catalyze the transfer of a methyl group of S-adenosylmethionine (SAM) to the fifth carbon position of cytosine 26