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10.1186/s12979-019-0147-x Immun

High-level TGF signalling is characteristic of many stroma-rich tumour types, including CMS4 CRC [3] and is a major metastasis-promoting signalling pathway in late-stage CRC [45]

Thresholds based on cluster size, estimated R 2 , and the number of nested CGs were applied to highlight regions most consistently supported across independent studies, following general M-QTL practices 86,87

Cells cultured in the above normal cell culture conditions were used as normoxia control

Their ability to regulate inflammatory responses and key signaling pathways make them potential therapeutic agents for treating renal fibrosis