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this property is thought to reduce the risk of return to use by blocking euphoria when co-ingested with lower affinity, recreational opioids [6]

PLoS One 14(9):e0222921

Here, we report the discovery of a series of fragment hits that bind at the interface between the TRFH domain of TRF1 (TRF1 TRFH ) and a peptide of TIN2 (TIN2 TBM ), an interaction essential for the recruitment of TRF1 to shelterin, using X-ray crystallography (XChem) and ligand-observed NMR (LO-NMR) fragment screening