chac1 er stress glutathione degradation A scheme of the mechanism of of enhancing Endoplasmic reticulum stress-mediated programmed cell

Endoplasmic reticulum stress mediated programmed cell death in the tumor microenvironment Cell Death Discovery Glutathione specific gammaglutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis Science Translational Medicine CHAC2 is essential for self renewal and glutathione maintenance in human embryonic stem cells ScienceDirect Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF CRE Regulatory Element ScienceDirect CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancers PMC

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