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The estimated background risk of major birth defects and miscarriage for the indicated populations is unknown

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* Correspondence: Fan Guo, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Pregnant women are recommended to consume the amount of vitamin B12 as advised by the Food and Nutrition Board, National Academy of Sciences-National Research Council, which is 4 mcg daily