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Shear stress-triggered nitric oxide release from Schlemms canal cells

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Each time a cell divides, telomeres shorten slightly, and once they become critically short, the cell can no longer replicate efficiently

Tris-HCl washing buffer) containing either [3H]raclopride (4 nM, 65 Ci/mmol, PerkinElmer) or a combination of [3H]SCH-23390 (2.5 nM, 83.6 Ci/mmol, PerkinElmer) with Ketanserin (40 nM, Tocris) in order to block off-target binding of SCH-23390 to serotonergic receptors

By mapping thousands of gene changes simultaneously, researchers can understand the broad biological impact of a compound not just one effect, but the entire network of changes it triggers