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Proc Natl Acad Sci 100:94409445 Su YW, Chen X, Jiang ZZ, Wang T, Wang C, Zhang Y, Wen J, Xue M, Zhu D, Su YJ, Xing TY, Zhang CY, Zhang LY (2012) A panel of serum microRNAs as specific biomarkers for diagnosis of compound- and herb-induced liver injury in rats

I think those things come down to an energetic deficit driving the predisposition

doi: 10.1016/0378-1119(96)00050-9 29 BalishMFHahnTWPophamPLKrauseDC

Cells exposed to varying percentage of oxygen showed increased reactive oxygen species and cell death

Research suggests the peptide may interact with neurotransmitter systems including the dopaminergic, serotonergic, and GABAergic pathways, though these findings remain in the preclinical stage