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The GHK-Cu group showed significantly greater total protein and collagen synthesis demonstrating that the peptide's effects on extracellular matrix accumulation extend to systemic injection, not just topical application

Metformin, a common diabetic drug is also a cause of B12 deficiency

The 2024 fusion-peptide work exists precisely because researchers recognized that native DSIPs delivery to the brain is the bottleneck, and engineered around it by fusing DSIP to a blood-brain-barrier-crossing TAT transduction domain (sequence GGGGYGRKKRRQRRR) via flexible GGGGS linkers, expressed and secreted from Pichia pastoris