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Indian Dermatol Online J 7(4):311315

Lysosomal destabilizing drug siramesine and the dual tyrosine kinase inhibitor lapatinib induce a synergistic ferroptosis through reduced heme oxygenase-1 (HO-1) levels

By selectively blocking NNMT, 5-Amino-1MQ is investigated for its ability to preserve cellular NAD+ pools, reduce methylation of nicotinamide to inactive 1-methylnicotinamide (1-MNA), and enhance sirtuin activity and energy metabolism

Figure 2 As cancer cells poorly absorb exogenous aspartate, GOT1/GOT2 support tumorigenesis by providing cytosolic aspartate (a precursor for nucleotide/protein synthesis) while constituting the malate-aspartate shuttlefacilitating NADH transfer across membranes to maintain redox balance (165)