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Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY: Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

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Amiodarone maintenance therapy can result in a dose-dependent incidence of either hypothyroidism (more commonly) or hyperthyroidism (more rarely)(Cohen-Lehman et al, 2010)

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However, the role of this metabolite in the progression of renal impairment is not well understood