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Translating Findings to Humans: Clinical Studies on Chronic Ethanol Consumption and Depression The translation of preclinical findings from animal models to human clinical studies represents a critical bridge in understanding the molecular underpinnings of ethanol-induced depression

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They also demonstrated that Fer-1 mitigates not only rotenone-induced apoptosis but also synuclein aggregation and ER stress

The mechanism behind these effects involves upregulating LDL receptor expression and inhibiting the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), critical for cholesterol synthesis (Qin et al., 2017)

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