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Funding Statement This study has been supported by the grant BWS21J001

The best food sources include yeast extract (Marmite/Vegemite), nutritional yeast flakes with B12, B12-fortified vegan milks, B12-fortified breakfast cereals and B12-fortified margarine

For active B12 deficiency, most clinicians recommend weekly or biweekly shots for the first 4 to 6 weeks, then a maintenance shot every 1 to 3 months

Researchers conduct most studies in preclinical settings, collect limited human data, and have not yet determined long-term systemic effects

The mechanism is still active in leaner individuals just with proportionally smaller output