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Acknowledgements This work was created as part of NCCR Catalysis, a National Centre of Competence in Research funded by the Swiss National Science Foundation (grant number 180544 to R.M.B) and by AEI (Spain) (grant number RTI2018-099592-B-C22 to G.J.-O)

Bithionol eliminates acute myeloid leukaemia stem-like cells by suppressing NF-B signalling and inducing oxidative stress, leading to apoptosis and ferroptosis

65 Furthermore, it also transmits signals in a noncanonical manner independent of HGF, which is an important mechanism for malignant cells to acquire resistance to inhibitors in pathological conditions

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Degradation of p62 is a marker of autophagy activity because, after binding to microtubule-associated protein 1 A/1B-light chain 3 (LC3), it is selectively degraded via autophagy [100]