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In addition, the untreated TBI group appeared to recover their motor function on this task and no longer displayed a significant difference from the Sham control group (Figure 5B)

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Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

The latter observation suggest that P-gp-basal or unstimulated ATPase activity could be the trigger for oxidative stress above the redox equilibrium threshold