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Nutr Metab (Lond) 2018;15:33.PubMedPMC 29

2004 Jun;9(2):157-79

CASIN exerts anti-aging effects through RPL4 on the skin of naturally aging mice

Constitutive activation of NRF2, mainly via loss-of-function mutations in the CUL3-adapter KEAP1 or gain-of-function mutations in NFE2L2 , is thought to provide a fitness advantage to tumor cells in confronting metabolic/oxidative stress resulting from dysregulated growth (DeNicola et al, 2011