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Chronic AS toxicity results in multiorgan system disease and the most serious consequences being the malignancy 55

A study conducted by Jain and colleagues demonstrated that the elevated mtROS generated at complex III are required for TGF--induced gene expression (193)

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In lupus-prone mice, 4-OI ameliorates renal immune complex deposition, decreases autoantibody production, and attenuates hyperactivation of immune cells via inhibition of JAK1 [64]

Lipid A is a unique and distinctive phosphoglycolipid, the general structure of which is highly conserved among species, although variations in the fine structure can arise from the type of hexosamine present, the degree of phosphorylation, and in the nature, chain length, number and position of the acyl groups