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The collagen-induced arthritis (CIA) model, a classic tool for investigating the pathogenesis of RA, exhibits significant gut microbial dysbiosis and metabolic abnormalities at 20 days after the initial collagen immunizationa preclinical stage prior to the onset of joint symptoms

Anas, M., et al

Epigenetics 13 , 54 (2021)

Chick embryos show a high requirement for L-carnitine, yet contain low levels of Lcarnitine, the injection of L-carnitine into the yolk sac would lead to circulation to fat storage areas such as the yolk sac to facilitate catabolism of fatty acids for energy

A surgeon may repair or replace the damaged joint