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Nevertheless, important concerns regarding among others precision or personalized medicine approaches must be addressed before using it in clinical practice, improving therapeutic outcomes across a broad range of malignancies

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Contrarily, CD11b upregulation in Munc13-4-knockout (KO) neutrophils was normal in response to the chemotactic peptide fMLF, a physiological stimulus that signals from plasma membrane receptors, further supporting that CD11b plasma membrane upregulation in response to CpG depends on TLR9 activation at endosomes 16

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