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Description

Methylcobalamin is also contraindicated in patients with cobalt hypersensitivity because methylcobalamin contains cobalt

Given that both MitoQ and DPI target mitochondrial function, we used the Loewe synergy model, which is particularly suited for evaluating the combined effects of drugs with similar mechanisms of action (36)

& Imai, S.-I

Phase 2b doses were 0.25 to 1.0 mg daily, which at a 2.5 mg/ml concentration means 0.1 to 0.4 ml per injection, conveniently measurable on a 1 ml insulin syringe