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While some studies have adjusted for APOE4 status in identifying AD-associated signatures 15,16 or vice versa 14 , such approaches may not adequately address the dominance of proteomic changes as well as unique and shared molecular signatures in relation to genotype and disease status

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Although stress is also a factor which may influence insulin resistance, no doctor treating individuals with diabetes would consider that those needing higher doses of insulin are mentally unstable, making up their disease, or suffering from the placebo effect

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