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Franzen, J., Moseti, C., Hartmann, J., et al

Steroid injections can take 3-5 days to take effect, but some patients are later responders, and it can take up to 2 weeks

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For instance, Atorvastatin, a Ras/MAPK inhibitor, showed encouraging results when evaluated in combination with radiotherapy and TMZ in patients with GBMs (Phase II NCT02029573) (50)

KRAS signalling has been linked to enhanced mitochondrial metabolism by various mechanisms in colorectal, lung and pancreatic cancers 8,18 , as has APC and p53 (refs