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Moreover, antioxidants quercetin (QE), baicalein (BE) and myricetin (ME) effectively downregulated ROS and MMP9 and inhibited glioma cell invasion/migration events in vitro ( However, some studies have shown that intake of antioxidants, such as carotenoids (371), vitamin E (372), and coffee (373), is not associated with the risk of developing gliomas

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Therefore, our study was intended to find the half maximal cytotoxic concentrations (IC 50 ) of GT, FUM and GT + FUM instead of solely relying on particular concentrations at in vivo conditions (Table 1)

Furthermore, inhibition of Rac1 activity by Rhein not only reduces oxidative stress but also affects downstream signaling pathways involved in EMT and renal fibrosis, such as the -catenin pathway (Xiong et al., 2023)