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However, we used leave-one-out sensitivity analysis under a conservative random-effects model to assess the possibility of some bias such as unclear double-randomization or large unbalanced dropout

Free Radic Biol

Although there are some links between TMAO and MAFLD and administration of TMAO impairs liver function and increases hepatic triglyceride accumulation and lipogenesis in animal models, whether reducing TMAO concentrations could prevent MAFLD remains unclear due to lack of relevant studies

[PubMed: 26699442] 639

Earlier experimental studies have shown that reactive oxygen species (ROS) and plasminogen activator inhibitor 1 (PAI-1) induced by initial insults penile tissues are remarkably increased in fibrotic plaques and then result in oxidative stress (Vernet et al., 2002