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Visible changes in brightness and evenness of skin tone may take several weeks to months, depending on baseline pigmentation, dose, route of administration, and adherence to sun protection. Results are often subtle and natural-looking, and ongoing maintenance may be required to sustain benefits, especially in individuals with high sun exposure

So there is plenty of evidence showing that Metformin and Vitamin B12 deficiency is a problem, especially with long term use of Metformin and this is a drug that is usually taken forever once it is prescribed Metformin And Vitamin B12 Deficiency The Solution The first thing to do is to get your vitamin B12 levels tested so that you have a baseline reading, dont follow the reference range but make sure your levels are over 400 as a minimum