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This process is governed by the angiogenic switch mechanism, where dynamic equilibrium between pro-angiogenic (e.g., VEGF/VEGFR axis) and anti-angiogenic factors (e.g., p53-mediated pathways) determines neovascularization outcomes (95)

This investigation was supported by grants from the National Natural Science Foundation of China (Grant Nos

Acknowledgements This work was financially supported by the National Natural Science Foundation of China (32172505 to J.L., 32272484 to H.P., 323B2055 to K.X.), the National Key Research and Development Program of China (2019YFE0114200 to H.P.), and the Natural Science Foundation of Jilin Province (20230101156JC to J.L.)

NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor-mediated currents

The Phase 2 data showed weight loss curves that had not plateaued, meaning longer treatment durations could push the numbers even higher