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[DOI] [PubMed] [Google Scholar] Kauffman K.J., Dorkin J.R., Yang J.H., Heartlein M.W., DeRosa F., Mir F.F., Fenton O.S., Anderson D.G

Their mechanism of action is mainly to inhibit the renin-angiotensin system (RAS), reduce the production of angiotensin II, and effectively improve endothelial cell function ( , IL-6) and pro-fibrotic factors, delay the fibrosis process of renal disease, and protect renal function ( 5.2 Cell therapy and gene therapy As an emerging cell therapy strategy, EPCs transplantation has brought new prospects for the treatment of renal diseases ( Gene therapy uses modern molecular biology technology to introduce specific functional genes into endothelial cells through vectors such as adeno-associated virus (AAV), lentivirus, or small interfering RNA (siRNA)