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They used random mutagenesis to generate over 3,500 individual IL-1a mutants that averaged 2.5 amino acid changes per variant over the entire length of the molecule

doi: 10.1073/pnas.0600306103 47 TanakaR.KobayashiK.MasudaT

If your research question centers on gene expression, angiogenesis, and cell migration without specific anti-inflammatory consideration, the three-peptide formulation has all the relevant components

Wells, Q

The PEG-charge-conversional polymer may improve upon the PEG-polyanion block copolymers by being cleaved into a polycation at acidic pH, thus enhancing endosomal escape